NEWSLETTER

Fields marked with "*" are required to fulfill.

Posts

Display: 1 - 40 of 100
Show on page: 20 | 40 | 100
  • Immune escape – Dr. Geert Vanden Bossche explained

    27/07/2021
    Posted by:

    Dr.M.Raszek


    This post examines the theories of Dr. Geert Vanden Bossche about virus immune escape. And specifically, his claims that mass vaccinations will potentially help develop immune escape variants of SARS Co-V-2 and why this could be very dangerous to everybody.


  • Pharmacogenetics evidence levels

    18/07/2021
    Posted by:

    Dr.M.Raszek


    Pharmacogenetics/pharmacogenomics is the study of how our genes impact the medications we take. Each one of us is programmed by having a variety of different mutations in our genes that influence how medications are processed by our body, and this information can be collected and then examined to help determine how medications should be dosed to best match how we metabolize (break down within our body) the medications we use, or even help avoid taking medication altogether because it could be toxic to us. Here we describe how the levels of evidence for pharmacogenetics are established.


  • Lab leak theory vs natural origin of SARS-CoV-2 – why past conflicts of interest might be driving the current debate

    26/06/2021
    Posted by:

    Dr.M.Raszek


    After a year long campaign of ridiculing and silencing any public suggestion that SARS-CoV-2 virus could have escaped from the Wuhan Institute of Virology laboratory, suddenly the media is very open to entertaining this notion. This is such a strange tale of how public perception is shaped by prevailing propaganda, but what we can say with high certainty is that the public’s perception in the US of the virus’ origin has so far been shaped by two figures with a staggering conflict of interest: Dr. Anthony Fauci and Dr. Peter Daszak.


  • Top list of patient signs for doctors to use DNA testing

    09/06/2021
    Posted by:

    Dr.M.Raszek


    This post is to inform doctors who are starting to realize the value of medical DNA testing and to inform them about the best indications that DNA testing should be strongly considered. DNA tests are selected for patients as a possibility to obtain a clearer clinical picture.


  • Genetic mutations that can cause Polycystic Kidney Disease

    22/05/2021
    Posted by:

    J.Hart and Dr.M.Raszek


    Polycystic kidney disease is a genetic disorder that can affect the kidneys. It causes cysts in the organs and makes them swell up, which over time could lead to renal failure if untreated. Polycystic kidney disease can be caused by mutations to different genes, some of which will be discussed in this post.


  • COVID-19 and genetic predisposition

    08/05/2021
    Posted by:

    Dr.M.Raszek


    Everyone in the world probably knows by now that if someone gets infected by SARS-CoV-2 virus, the resulting impact can range from a complete lack of symptoms to severe respiratory failure leading to death. Obviously, one possible contributing factor that would be worth investigating is the role of our personal genetics. So, what have we learned so far?


  • Clinical DNA testing options selection guide

    25/04/2021
    Posted by:

    Dr.M.Raszek


    This post explains the different DNA testing options available to patients/consumers who seek to discover potential genetic causes of an already existing condition. The testing also applies to a person who wants to screen before any clinical symptoms of a condition become apparent.


  • Cytomegalovirus fetus infection and pregnancy outcomes

    11/04/2021
    Posted by:

    Dr.M.Raszek


    With all the attention of the COVID-19 causing virus (SARS-CoV-2), we have been bumping into lots of literature related to viruses in general and one virus in particular grabbed our attention as it has been reported to be the leading cause of birth defects in newborns worldwide. The virus of interest is the human cytomegalovirus (CMV) which belongs in the herpes viruses family.


  • How pharmacogenomic classification of tumors is driving forward precision cancer therapy

    22/03/2021
    Posted by:

    D. Hernandez


    Anticancer drug therapy, widely known as chemotherapy, uses medication to kill or slow down cancer cell growth. However, its effectiveness has huge fluctuations between individuals. The outcomes in some people are promising, while the same anticancer drug might have little to no effect in others with the same classification of tumor. The unpredictability of anticancer therapy outcomes is due to the diversity of genetic backgrounds of each patient. This is where precision oncology comes in. Defining a genetic characterization for individual tumors and how they will respond to anticancer drugs is key in guiding optimal patient tailored therapy on a case-by-case basis.


  • Vaccine adverse side effects: how do COVID-19 vaccines compare?

    17/03/2021
    Posted by:

    Dr.M.Raszek


    This article is based on the information that is reported in a publicly available database compiled by the US Center of Disease Control and Prevention (CDC), termed the Vaccination Adverse Events Reporting System. This database was set up approximately 30 years ago to allow anyone to report any side effect (whether adverse or non-adverse) suspected to be from taking a vaccination. The idea of the database is to be able to capture any worrisome events and allow rapid investigations of vaccine safety. We hope we have got your curiosity going enough to now check out what this database has shown so far for the different vaccines, and especially how that might compare to the new mRNA COVID-19 vaccines. The results are definitely captivating.


  • Caring for caregivers, the Alberta way!

    27/02/2021
    Posted by:

    Dr.M.Raszek


    There are 1 million caregivers in Alberta! That means the non-paid, non-professional people often are working, are raising children, have their own lives while taking on this additional role to help someone else live, people with disabilities, with health challenges and with aging-related needs. A lot of the caregiving role leads to emotional burnout. Caregivers Alberta was created by caregivers to support caregivers, working with clients on increasing their resiliency and their ability to bounce back from stressful situations and crises.


  • Could COVID-19 have actually originated many years ago?

    16/02/2021
    Posted by:

    Dr.M.Raszek


    In the summer of 2020, a curious hypothesis came out that perhaps COVID-19 actually emerged many years prior in China. This hypothesis was based on the fact that in 2012 six miners became severely ill with a mysterious inflammatory lung disease. Drs. Latham and Wilson proposed that SARS-CoV-2 could actually have evolved in the lungs of the miners that became ill after being infected with a bat virus. One major problem with this hypothesis was that there was no prior scientific evidence that human lung tissue could act as an environment that could drive the substantial mutational changes that would be required for adaptation of a bat virus to a human-infectious virus. However, thanks to the current pandemic taking place around the world, it appears that we finally have evidence that this indeed can happen.


  • Genetics of cheating

    08/02/2021
    Posted by:

    Dr.M.Raszek


    For the past couple of years, in celebration of Valentine’s Day, Merogenomics has posted articles dedicated to the genetics that concern romantic relationships. We started the trend with the genetics of sexuality, then last year we moved to the genetics of love, and we wanted to play a “dirty” joke by completing the trinity of relational aspects with a topic dedicated to… the genetics of cheating!


  • Most gossiped about genetic news of 2020

    21/01/2021
    Posted by:

    Dr.M.Raszek


    For a fifth year in a row, we review the most shared genetic stories on social. The only metric we look at is the highest number of shares for any content related to genetics. These are all over the board, from absurd to celebration of our greatest achievements, DNA-related stories that captured our imagination the most in 2020!


  • The new UK SARS-CoV-2 strain – a first science info analysis

    11/01/2021
    Posted by:

    Dr.M.Raszek


    This story of a UK new SARS-CoV-2 strain exemplifies how rapidly the leaders are willing to respond to maintain the general safety of the populatio. How the decision was made to proclaim the emergence of this new threatening strain is not discussed in the media and very few have actually probed for its scientific merit. But are you curious, where did it come from? Very few people get to peak behind the curtains.


  • COVID-19 mRNA vaccines – what does the initial data show?

    25/12/2020
    Posted by:

    Dr.M.Raszek


    This article does not have an agenda to support vaccination program or vilify it. Meaning Merogenomics is not married to a camp of anti-vaxxers, or those who think everyone should be vaccinated (because not everyone is actually eligible to be vaccinated), and the purpose is to produce an article that looks at data to see how many questions of interest can be answered. Look at the image above to see what we attempted to answer. Benefits and limitations of these novel mRNA vaccines.


  • COVID-19 PCR tests – are we over-testing or under-testing? Who is right?

    06/12/2020
    Posted by:

    Dr.M.Raszek


    There is a massive public debate going on about the COVID-19 pandemic threat. Wherever you might stand on the spectrum of this debate - whether you decry anytime someone dares to step outside into the fresh air, or you belittle the existence of this infection as nothing more significant than a bad flu – there is one argument used by either side that gets a lot of collateral damage: the use of PCR tests to diagnose the infection with the SARS-CoV-2 virus. So where do we really stand on these PCR tests? Which side might be right and which side is wrong? Let's look at the science behind these PCR tests! You just might be surprised by what you find out.


  • Autism spectrum disorders and DNA testing

    23/11/2020
    Posted by:

    Dr.M.Raszek


    Everyone knows how the incidence of autism has been on a constant rise over the years (currently approximately one in 54 children in the US and one in 66 in Canada). But what is not broadly understood in the general public is that genetics play a massive contribution in autism spectrum disorders. In turn, it is also not widely known that identifying the genetic factors in an affected autistic individual can help to more specifically discriminate the condition.


  • Progress in the world of medical genetics 2020

    07/11/2020
    Posted by:

    Dr.M.Raszek


    There were many great themes emerging from the 2020 American Society of Human Genetics conference. The biggest take home message is that medical genetics continues to grow at an enormously rapid pace, with consistently more patients all over the world having their DNA sequence decoded to help with their medical management and to help discover novel causes of the conditions affecting them - from rare diseases to more common health issues such as breast cancer or hyperlipidemia. Even really complex traits like infertility are being probed for influencing genetic factors. No condition escapes the microscope and some completely new diseases are described as well. It is becoming clear that medicine will be dramatically reshaped. Read on to find out why.


  • Fake viruses? SARS-CoV-2 origins conspiracy theories Part 3

    21/10/2020
    Posted by:

    Dr.M.Raszek


    The last two blog posts we have dedicated to going over a controversial, non-peer reviewed online report outlining reasons why the SARS-CoV-2 virus could not have been of natural origin. The authors promised to follow up that initial report with further proof of why a number of published coronavirus genomes from different animals are fake. We were really curious what kind of evidence they would propose to build their case to claim an academic fraud of such massive proportion, and this is what this post is about.


  • SARS-CoV-2 coronavirus origins alternative theories – do they hold up against science? Part 2

    10/10/2020
    Posted by:

    Dr.M.Raszek


    This is the second post of a two part series dedicated to analyzing the conspiracy theories regarding the SARS-CoV-2 origins that are different from the widely accepted “natural origin”, where we offer a contradictory, equally controversial viewpoint to a synthetic origin theory, and review the authors’ “smoking gun” evidence of why the SARS-CoV-2 was engineered.


  • SARS-CoV-2 coronavirus origins alternative theories – do they hold up against science? Part 1

    28/09/2020
    Posted by:

    Dr.M.Raszek


    Earlier this month a deeply controversial and outright shocking report came out purporting to provide smoking gun evidence that SARS-CoV-2 coronavirus was laboratory engineered. With a title like "Unusual Features of the SARS-CoV-2 Genome Suggesting Sophisticated Laboratory Modification Rather Than Natural Evolution and Delineation of Its Probable Synthetic Route" this report promised to have some incriminating statements so obviously we were going to investigate it, and see how the published science stacked against their claims.


  • What is genetic mosaicism?

    15/09/2020
    Posted by:

    Dr.M.Raszek


    In this post we will discuss what might seem like an obscure topic but is a very real-life issue: being composed of more than one genome. Or in other words, situations where an individual carries two different types of genetic information in the cells of their body. This is especially significant for those who are interested in prenatal DNA testing.


  • Pharmacogenetics DNA test best use

    31/08/2020
    Posted by:

    Dr.M.Raszek


    Traditionally medicines have been developed to target entire populations. However, patient’s individual biological influences can dramatically shift drug effectiveness in comparison to just the population average. For this reason medication efficacy can actually be astonishingly low for any given person - far lower than people probably realize. We now have the means to start probing this information of how to properly match medications to an individual. It is based on a person’s genetics especially the specific mutations in a person’s DNA code that can result in differences in how we biologically react to a specific medication. This is referred to as pharmacogenetics.


  • Hearing loss DNA testing

    08/08/2020
    Posted by:

    Dr.M.Raszek


    In this post we wanted to recount the story of a family with children that presented with hearing loss with no prior family history. It turned out to be very unique account of unsuspected genetics - a paradigm that will continue to happen with greater frequency as more people chose to analyze their DNA. This story demonstrates the potential power of proactive screening of one’s genetic state, and even hints at when it might become a necessity with regards to planning a family.


  • Variants of Unknown Significance (VUS) – doctors beware!

    27/07/2020
    Posted by:

    Dr.M.Raszek


    We start with the story of a cancer survivor who just recently completed an advanced DNA/RNA sequencing combo test for cancer predisposition; it was not only the very first time this test was used in Canada, it was the first time it was used anywhere in the world outside of US. This test is so new that we were a little bit jealous that the patient would end up seeing the DNA testing kit even before Merogenomics had the chance to analyze one!


  • DNA testing for cancer patients

    14/07/2020
    Posted by:

    Dr.M.Raszek


    Last month we published a post on DNA testing for cancer predisposition and had an accompanying video on the types of DNA tests that are available for those people either afflicted with cancer or that have a family history of cancer. This month we wanted to focus on those tests available to cancer patients, as mentioned in our video. We’ll start by explaining how cancer patients can benefit from DNA testing.


  • Human genome project twenty years later

    26/06/2020
    Posted by:

    Dr.M.Raszek


    On this day (June 26th) in 2000, the completion of a working draft of the human genome reference was announced by President Bill Clinton. Today you can sequence your entire genome in mere hours but the very first human genome sequence that was decoded was an enormous undertaking of thousands of scientists from around the world in a project spanning more than a decade and at an estimated cost of $3 billion dollars of taxpayers’ money! And like any good story, there always has to be some controversy.


  • Cancer predisposition DNA testing options

    08/06/2020
    Posted by:

    Dr.M.Raszek


    This article is for anyone who is interested in learning about their potential genetic cancer predisposition that might have contributed to the onset of an existing or prior condition, or for those who have not developed cancer yet, but are worried they might be predisposed due to family history, and what DNA testing options might be available to them.


  • Benefits of clinics using medical DNA testing

    25/05/2020
    Posted by:

    Dr.M.Raszek


    There are many reasons why medical clinics should considering adopting DNA testing to benefit their patients. The vast majority of doctors are already aware that DNA testing has had a huge impact in helping patients. But the problem is that many doctors are not familiar enough with this technology and how to best implement it in their practice. Here are the top benefits to consider in overcoming these barriers.


  • Antibodies against SARS-CoV-2

    25/04/2020
    Posted by:

    Dr.M.Raszek


    We naturally build antibodies against infectious agents that we come into contact with. Thus if someone gets infected with SARS-CoV-2 virus then they will produce antibodies against it. But now imagine, it would be pretty handy if you could have access to such antibodies without the need of infection. So how do we get our hands on such antibodies that we could use for treatment?


  • Options for prevention of COVID-19, options for treatment of COVID-19. What does research find?

    07/04/2020
    Posted by:

    Dr.M.Raszek


    Perhaps this article is massively overdue. It is in fact a continuation of what we touched upon in our very first foray into studying the structure of SARS-CoV-2, when we mentioned one study which looked into potential compounds that could inhibit viral infection. The need for this story has since massively expanded, so in this post we will take you so deep that we peer into atomic structures and traverse the landscapes of biological molecules and list some our favourite chemicals that we found that might have protective capabilities against COVID-19!


  • COVID-19 coronavirus and ethnicity differences

    20/03/2020
    Posted by:

    Dr.M.Raszek


    One of the more compelling questions that has been asked around with regards to the Wuhan coronavirus is whether it infects different ethnic groups to a different extent. One paper was published recently that attempted to answer that question, and showed that indeed there could be racial differences for coronavirus infection based on what type of genetic mutations different populations might have. So let’s break it down.


  • Wuhan corona virus uniqueness – what does science say?

    09/03/2020
    Posted by:

    Dr.M.Raszek


    The origin of the SARS-CoV-2 virus has not been conclusively demonstrated. Meaning we do not know how it started to infect humans. There has been a tremendous amount of confusion and rumours with regards to whether this virus was human engineered rather than originating from nature. So let’s pose the nasty question: could the virus be synthesized by humans? To answer this we will dive deep into current scientific understanding of the architecture of this virus, and find out what makes SARS-CoV-2 coronavirus unique enough to have stirred so many controversies so quickly.


  • Can you hear the music?

    29/02/2020
    Posted by:

    C.Degenhardt


    To commemorate international Rare Disease Day 2020, we have a story of two boys growing up together, one with a rare disease, one without. A story that teaches us to appreciate the beauty that is gifted to us sometimes in most unexpected manner.


  • Genetics of love

    09/02/2020
    Posted by:

    Dr.M.Raszek


    Could love be genetically driven? There seem to be strong arguments that say yes. The components of adult romantic love are actually similar to the intense love between parents and infants. It has been proposed that the already existing design used for offspring caring might have been evolutionarily adopted for use between the mates. There is support for the notion that romantic love and parental offspring bonding share a biological signature, including genetic footprint underpinning it.


  • Human genome DNA test costs – how low can you go?

    30/01/2020
    Posted by:

    Dr.M.Raszek


    If you are looking at decoding your own genome, there are a plethora of options available to you and if you start doing your research (as we would hope you would!), you will soon discover a very wide range of genetic testing cost options. In fact, so wide, it will be at least a factor of 10! So what gives? What is the appropriate price for decoding your genome?


  • Most gossiped about genetic news of 2019

    12/01/2020
    Posted by:

    Dr.M.Raszek


    It is that time of the year again where we continue our tradition of looking at some of the most frequently shared articles on social media relating to DNA and genetics. These vignettes are in stark contrast to the typical information shared on the Merogenomics blog which is carefully vetted for scientific accuracy - but just as entertaining to read. Also unlike the typical content of the Merogenomics blog, the content produced for social media’s viral output can at times be absolutely outrageous!


  • Genetic editing legacy – update on the first designer babies

    31/12/2019
    Posted by:

    Dr.M.Raszek


    The creator of first live-birth designer babies was sentenced to three years in prison yesterday. It has been just over a year since the news of the world’s first genetically designed babies was announced in China. A young, very well-connected and aspiring scientist who was not only interested in the accepted genetic editing methods but was also seemingly hiding a secret - that he had produced the first genetically engineered embryos used to give birth to live children! It shocked the world and then condemnations swiftly followed. We explore was done wrong.


  • Latest genetic editing – targeting anything anywhere

    06/12/2019
    Posted by:

    Dr.M.Raszek


    Since its discovery, a massive amount of research (and money) has gone into CRISPR/Cas9 technology to modify it for the needs of research and clinical use. In the latest and most advanced rendition of CRISPR technology, the molecular machinery can now find a desired target and deliver any type of DNA change desired without the need of introducing double-stranded DNA breaks (breaking the DNA apart essentially) or without using a DNA template to produce the change. The leap forward is simply mind boggling.


Display: 1 - 40 of 100
Show on page: 20 | 40 | 100