NEWSLETTER

Fields marked with "*" are required to fulfill.

Doctors

Display: 1 - 20 of 29
Show on page: 20 | 40 | 100
  • Pharmacogenetics evidence levels

    18/07/2021
    Posted by:

    Dr.M.Raszek


    Pharmacogenetics/pharmacogenomics is the study of how our genes impact the medications we take. Each one of us is programmed by having a variety of different mutations in our genes that influence how medications are processed by our body, and this information can be collected and then examined to help determine how medications should be dosed to best match how we metabolize (break down within our body) the medications we use, or even help avoid taking medication altogether because it could be toxic to us. Here we describe how the levels of evidence for pharmacogenetics are established.


  • Top list of patient signs for doctors to use DNA testing

    09/06/2021
    Posted by:

    Dr.M.Raszek


    This post is to inform doctors who are starting to realize the value of medical DNA testing and to inform them about the best indications that DNA testing should be strongly considered. DNA tests are selected for patients as a possibility to obtain a clearer clinical picture.


  • Clinical DNA testing options selection guide

    25/04/2021
    Posted by:

    Dr.M.Raszek


    This post explains the different DNA testing options available to patients/consumers who seek to discover potential genetic causes of an already existing condition. The testing also applies to a person who wants to screen before any clinical symptoms of a condition become apparent.


  • Autism spectrum disorders and DNA testing

    23/11/2020
    Posted by:

    Dr.M.Raszek


    Everyone knows how the incidence of autism has been on a constant rise over the years (currently approximately one in 54 children in the US and one in 66 in Canada). But what is not broadly understood in the general public is that genetics play a massive contribution in autism spectrum disorders. In turn, it is also not widely known that identifying the genetic factors in an affected autistic individual can help to more specifically discriminate the condition.


  • What is genetic mosaicism?

    15/09/2020
    Posted by:

    Dr.M.Raszek


    In this post we will discuss what might seem like an obscure topic but is a very real-life issue: being composed of more than one genome. Or in other words, situations where an individual carries two different types of genetic information in the cells of their body. This is especially significant for those who are interested in prenatal DNA testing.


  • Pharmacogenetics DNA test best use

    31/08/2020
    Posted by:

    Dr.M.Raszek


    Traditionally medicines have been developed to target entire populations. However, patient’s individual biological influences can dramatically shift drug effectiveness in comparison to just the population average. For this reason medication efficacy can actually be astonishingly low for any given person - far lower than people probably realize. We now have the means to start probing this information of how to properly match medications to an individual. It is based on a person’s genetics especially the specific mutations in a person’s DNA code that can result in differences in how we biologically react to a specific medication. This is referred to as pharmacogenetics.


  • Variants of Unknown Significance (VUS) – doctors beware!

    27/07/2020
    Posted by:

    Dr.M.Raszek


    We start with the story of a cancer survivor who just recently completed an advanced DNA/RNA sequencing combo test for cancer predisposition; it was not only the very first time this test was used in Canada, it was the first time it was used anywhere in the world outside of US. This test is so new that we were a little bit jealous that the patient would end up seeing the DNA testing kit even before Merogenomics had the chance to analyze one!


  • DNA testing for cancer patients

    14/07/2020
    Posted by:

    Dr.M.Raszek


    Last month we published a post on DNA testing for cancer predisposition and had an accompanying video on the types of DNA tests that are available for those people either afflicted with cancer or that have a family history of cancer. This month we wanted to focus on those tests available to cancer patients, as mentioned in our video. We’ll start by explaining how cancer patients can benefit from DNA testing.


  • Cancer predisposition DNA testing options

    08/06/2020
    Posted by:

    Dr.M.Raszek


    This article is for anyone who is interested in learning about their potential genetic cancer predisposition that might have contributed to the onset of an existing or prior condition, or for those who have not developed cancer yet, but are worried they might be predisposed due to family history, and what DNA testing options might be available to them.


  • Benefits of clinics using medical DNA testing

    25/05/2020
    Posted by:

    Dr.M.Raszek


    There are many reasons why medical clinics should considering adopting DNA testing to benefit their patients. The vast majority of doctors are already aware that DNA testing has had a huge impact in helping patients. But the problem is that many doctors are not familiar enough with this technology and how to best implement it in their practice. Here are the top benefits to consider in overcoming these barriers.


  • Alberta Health Services genetic testing 2019 overview

    06/11/2019
    Posted by:

    Dr.M.Raszek


    The world of genetics and genomics is vast both in private access to medical genetics as well as public. But how vast is it here in Alberta? We catalogued all of the different tests available in the Alberta Health Care Genetics and Genomics program.


  • Birth defects

    10/10/2019
    Posted by:

    J.Phillips


    Birth defects are disabilities and disorders that are present in an infant from the time of their birth. They affect approximately 1 in 25 newborns each year. 1 in 5 newborn deaths result from birth defects primarily due to defects of the heart, lungs, brain, and contribution of genetics. Since birth defects have such a profound impact on both the lives of families and society as a whole, it makes sense that a lot of effort is focused on treatment and prevention.


  • Childbirth pharmacogenetics

    09/09/2019
    Posted by:

    Dr.M.Raszek


    Part of modern medicine’s benefit in the childbirth process is the array of medications available to a mother during labour (depending on her requirements). A client of Merogenomics who has undergone full genome sequencing, later became pregnant and wondered if her collected DNA data could be used in relation to any medications that might be provided to her during the childbirth process. In other words, is there any evidence that person’s DNA could be used to specifically personalize prescriptions and the dosing of drugs used during childbirth?


  • 23andMe health reports - how accurate are they? 23andMe review part 2

    30/08/2019
    Posted by:

    Dr.M.Raszek


    This is a second article of two dedicated to reviewing 23andMe DNA based health reports. We continue the 23andMe review with what impresses us about their process, what does not, and where should medical doctors stand when it comes to 23andMe results.


  • DNA carriers can be in trouble too

    23/07/2019
    Posted by:

    Dr.M.Raszek


    If only one of the two genes is mutated, the person is considered a carrier, and typically is not affected by the disease. In essence, the other good copy of the gene inherited from one of the parents rescues the deficiency of the broken gene that was inherited from the other parent. But DNA mutation carriers can sometimes exhibit some disease symptoms too. The patient’s understanding of their history might have to act as the guiding parameter, judged by the test ordering doctor if the condition should be further screened for or not.


  • What is a carrier status in DNA sequencing?

    02/07/2019
    Posted by:

    Dr.M.Raszek


    When you are planning to sequence your whole genome, decoding the sequence of your entire DNA, reproductive planning might not be on the top of your list of motivating reasons in which to do so. Many might not even appreciate that is actually one of the major benefits of genome sequencing. It allows figuring out how partners who want to have kids can match their DNA against the odds of passing on mutations to their children that could cause diseases.


  • What is genetic counselling?

    25/05/2019
    Posted by:

    J.Phillips


    If you or someone in your family has been diagnosed with a genetic disease then chances are you’ve already heard of genetic counselling, but many people have not. Genetic counselling is a very unique service provided in the healthcare industry. In a system that is focused on diagnosing and treating as many patients as possible, many doctors simply don’t have the time to sit down with their patients and help them understand all of the components of genetic disease and how to adapt to the changes in life that disease brings. This is where genetic counselling comes in. Being confronted with a genetic disorder can be a very overwhelming experience, and if you’ve found yourself in that position it is likely that you will have many questions.


  • Pregnancy screening options and the role of NIPT

    31/03/2019
    Posted by:

    Dr.M.Raszek


    The primary concern and screening available for women is that for chromosomal abnormalities. Until the recent introduction of non-invasive prenatal testing (NIPT), the screening program consisted of testing for specific blood markers (whether protein molecules or smaller chemicals) and an ultrasound, in the first and second trimesters of pregnancy. According to obstetrics guidelines, pregnant woman is supposed to be clearly told about her screening and testing options, and that includes traditional approaches, NIPT and even diagnostic invasive testing. Diagnostic invasive testing carry small but real risk of pregnancy loss. This is the primary reason why NIPT has gained so much in popularity because women don’t want to undergo diagnostic testing if they don’t have to, and place their pregnancy at risk. But because traditional screening is nowhere near as accurate as NIPT, with traditional screening, lots more women end up undergoing confirmatory diagnostic testing that they would not have to if they took the NIPT test in the first place.


  • The value of DNA sequencing at birth

    31/01/2019
    Posted by:

    Dr.M.Raszek


    Can sequencing at birth identify genetic findings that are potentially life-saving? Finally, the first results from the BabySeq project which investigated the impact of full genome sequencing in babies soon after birth suggest that DNA testing can uncover the risk of childhood-onset disease in much higher rates than previously anticipated, at nearly 10% of infants (9.4%). We are talking about conditions that were otherwise completely unanticipated to be present in these children based on their appearance, clinical examination, or family history. Furthermore, adult-onset conditions, which are typically not recommended to be investigated in children, were discovered at a rate of 3.5% in otherwise presumed healthy infants.


  • The top three protections for physicians using genomic medicine

    31/12/2018
    Posted by:

    Dr.M.Raszek


    Are you a doctor who wants to adopt genomic medicine now?

    Are you a doctor who has already introduced the use of DNA sequencing in your practice to assist your patients in their medical care, and want to make sure that the technology is used safely for the benefit of all patients?

    Or are you a doctor who simply encounters DNA sequencing test results, and wonders about the validity of the results or the safe practice use of such results?

    The following are the three most basic, but critical, steps to help you ensure safe practices, protect your patient from the harm of any test misuse, and at the same time, protect yourself and your practice from liability.


Display: 1 - 20 of 29
Show on page: 20 | 40 | 100