A compilation of the most shared genetic stories of 2022 sorted by what fascinated the public the most - as always, ranging from super cool to super absurd.

Clotting is capturing attention as a frequent complication associated with COVID-19. This post reviews the basics of: how clotting happens; how it is dissolved; what problems it may cause; and how is it treated.

Inflammation is very familiar to us and we know it can be bad. But how and why does it exist in the first place? In this post we explain inflammation as an innate immunity defensive mechanism and also how it can be a double-edged sword. Plus, how to stay on top of it.

In this post, we talk about the mystery behind why the COVID-19 mRNA vaccines had to be chemically manipulated to achieve their success and what this chemical alteration consisted of, and then we ask questions about what it means for any further potential biological impacts because so many gaps in the knowledge of this new technology need to be filled.

We review the intricate genetics of the immune system that could contribute to the development of endometriosis including the different stages of progression as well as factors that might protect against the disease development. This article highlights how complex conditions such as endometriosis can have complex genetic contributions involved in its development.

Predictions of outcomes for the ongoing pandemic of SARS-CoV-2 are scarce. One notable exception is Dr. Geert Vanden Bossche who early on warned that mass vaccination during a pandemic would have dire consequences on the population immunity. Here Merogenomics provides a simple graphical chart along with detailed explanations of his thoughts on the complex interplay between viral infection and the effect on the immune system in vaccinated versus unvaccinated individuals.

A very unusual potential pathway to cancer development has been proposed from mRNA vaccines (but so far completely unconfirmed). It involves the vaccine’s mRNA independently adopting a certain 3D shape that is different from the expected 3D shape of a SARS-CoV-2 RNA that codes for production of the spike protein. This different 3D shape of the vaccine’s mRNA would then lead to an unexpected binding of cellular proteins and RNA, removing them from their native function. If this interference of normal function became great enough, it would have the potential to promote cancer development.

Mitochondrial donation is an emerging reproductive technology applicable to women who suffer from mitochondrial disease. In this blog, we firstly summarize what mitochondrial donation is and how it is being regulated. Secondly, we explore ethical issues that arise beyond the scope of traditional artificial reproductive technologies as a result of the unique features of mitochondrial donation.

There's no doubt that doctors are some of the most highly respected and well-paid professionals in the world. And with that comes a great deal of responsibility, which is why it’s so important for doctors to take steps to protect their patients from medical malpractice and negligence. This article will discuss some of the best steps doctors can take to avoid accidentally falling into such a trap.

The Omicron appears to have become one of the most infectious viruses we ever had to contend with - the exact opposite trend of what we wanted to accomplish during the management of the pandemic, which was to dramatically decrease the transmission of the virus in the population. But no one is asking why this has happened? For this reason, we were highly interested in Dr. Bossche’s latest blog post pertaining to why the Omicron is both more infectious and milder in nature than previous variants, and how this development could be leading to the future progression of the pandemic.

In this article, we are going to look at one proposed mechanism of how vaccine mRNA could be negatively affecting immune response in certain individuals through exosomes.

Recently Merogenomics has published a video on a scientific investigation into whether vaccines might be influencing the menstrual cycle and/or the duration of menses. What followed was hundreds of comments on what so many women have experienced, and who described their extreme experiences in detail. We decided to present it in a graphical format, at least until we see a proper scientific analysis of these extreme outcomes being reported!

There is a small unvaccinated minority of people who already have to contend with certain added health difficulties on account of their existing health problems. Here we propose some exemption criteria that should be strongly considered in specific situations expressed to doctors by patients expressing their understandable fear of the risks of accidentally worsening their already existing disabilities by unusual vaccine adverse event.

The field of medicine is working hard to keep up with advances in genome sequencing technologies but remains far behind due to difficulty in implementing some of the new, unfamiliar, and expensive protocols. Here we have focused on recent research and developments in clinical genomics, intending to highlight some of the progress being made towards optimization and large-scale implementation of genome sequencing in clinical settings.

At the end of every year we like to see what online articles tied to DNA have captured the most attention, and we rank the top 10. One consistent theme is that typically these will be the stories with the most emotionally gripping content of the past year! So, what did we find this year?

We struggled to find a good summary of the Omicron mutations especially as to why the authorities were so concerned about originally. So, we did bit of our own research. This post looks at different predictive models of what might be expected from the Omicron, and the possibility that Omicron could be an early example of immune escape from vaccines.

This post is about possible unusual findings in a human genome of a presence of what is referred to as supernumerary marker chromosome - an independent fragment of a chromosome derived from any of our naturally occurring chromosomes. In essence, a person ends up having an additional tiny chromosome, and the clinical consequences of this can be quite varied.

In this post we summarize what Merogenomics perceived as the biggest themes in current medical genomics from the the latest conference put on by the American Society of Human Genetics. We also mention what themes are emerging, what is the usual information and what did not get as much attention as we might have expected.

This list of genes is extremely valuable for any doctor dealing with medical genomics as it consists of genes not only vetted for their association to a condition, but these are also genes where a medical actionability is available to the doctors. In this context, actionability refers to available medical intervention as defined by current standards of care.

Technology is not waiting for clinical practice to adjust itself to what is already available to doctors - the research is always continuously evolving to deliver ever increasing benefits.

Future of Next Generation Sequencing 2021 virtual summit review.